Biologically useful conjugates.

摘要

Biologically useful conjugates are disclosed which are obtained by joining a paramagnetic or radionuclide metal ion with a biologically useful molecule (other than a Fab' fragment of an antibody, by means of a bifunctional coupling agent. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.