发明名称 |
WERKWIJZE VOOR HET BEREIDEN VAN EIWITMATERIAAL MET HORMONALE ACTIVITEIT UIT DE THYMUS, EN PREPARAAT DAT DERGELIJK EIWITMATERIAAL BEVAT. |
摘要 |
RAN 4090/93 A solid stable endotoxin and pyrogen free form of thymosin fraction 5 preparation containing (a) a major amount of thymosin fraction and minor, effective amounts each of (b) a phenolic type antimicrobial agent, and (c) a buffering agent in an amount sufficient to provide a pH of 7-8 on reconstitution and method for preparing same which method comprises (a) ultrafiltering an aqueous solution of thymosin fraction 5 buffered with a volatile weakly basic buffer to a pH of 7 to 8 through a membrane having a molecular weight cut off of about 10,000, (b) adding a phenolic type antimicrobial agent to the permeate and a buffering agent in anmount sufficient to provide of pH of 7-8 on reconstitution and (c) lyophilizing the permeate. |
申请公布号 |
NL189281(C) |
申请公布日期 |
1993.03.01 |
申请号 |
NL19780001422 |
申请日期 |
1978.02.07 |
申请人 |
F. HOFFMANN-LA ROCHE AG TE BAZEL, ZWITSERLAND. |
发明人 |
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分类号 |
A61K35/24;A61K38/22;A61P37/00;(IPC1-7):A61K37/02 |
主分类号 |
A61K35/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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