Antidepressant 3-Halophenylpiperazinyl-propyl Derivatives of Substituted Triazolones and Triazoldiones.

摘要

Compounds of Formula I <CHEM> or a pharmaceutically acceptable acid addition salt and/or hydrate thereof wherein R is halogen and trifluoromethyl; X is oxygen and acetyl; the single and dotted lines represent either a covalent single or double bond; n is an integer from 2 to 4; and Z is hydrogen and <CHEM> in which R<1> is hydrogen, halogen, C1-4 alkoxy and trifluoromethyl, which are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.