发明名称 |
PHARMACEUTICAL EMULSION CONTAINING BIOLOGICALLY ACTIVE STEROIDS AND METHOD OF EMULSION PREPARING |
摘要 |
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to new emulsions of type "oil-in-water" that can be used for parenteral administration into the body biologically active steroids exhibiting the limited solubility in usual solvents. Lipid phase of an emulsion has castor oil and phospholipid emulsifier made of an egg yolk. The content of components per 1 ml of an emulsion is the following: steroid from 0.1 to 15 mg, castor oil from 50 to 200 mg and an emulsifier - an egg yolk phospholipids from 5 to 50 mg. For emulsion preparing steroids are dissolved in lipid phase and the formed steroid-lipid phase is emulsified in an aqueous phase containing water and an egg yolk phospholipids. The novel emulsion has significant amounts of steroids dissolved in lipid phase in combination with increased physical and chemical stability that results to decrease of the total lipid loading and amounts of solubilizing and stabilizing agents administrated in the patient organism. EFFECT: improved quality and properties of an emulsion. 8 cl, 5 ex |
申请公布号 |
RU2141313(C1) |
申请公布日期 |
1999.11.20 |
申请号 |
RU19950108891 |
申请日期 |
1994.07.01 |
申请人 |
FARMATSIJA EHND APDZHON AB |
发明人 |
KHALL'GRIMUR JONASSON;PUJONG LI;TOMAS STENSTREM;KENNET ROSENKVIST;ANN MALINIAK |
分类号 |
A61K9/107;A61K31/56;A61K31/57;A61K47/24;A61K47/44;(IPC1-7):A61K9/107 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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