| 摘要 |
PROBLEM TO BE SOLVED: To obtain in a high yield, an optically active alcohol at a high enantiomer excess ratio using a small amount of a catalyst by the hydrogen- transfer type asymmetric reduction of a specific ketone by a specific amount of formic acid as a hydrogen donor in thepresence of a specific catalyst and an amine. SOLUTION: This composition shown by formula II is obtained by the hydrogen-transfer type asymmetric reduction of (A) a ketone shown by formula I [R<1> and R<2> are each a (substituted) aromatic hydrocarbon, an aliphatic hydrocarbon, an alicyclic hydrocarbon, or a heterocyclic group, or can form a ring together] by (B) formic acid at a 1-100 molar ratio to component A as a hydrogen donor in the presence of (C) a transition metal catalyst and (D) a tertiary amine (e.g. triethylamine) in an excess amount to component C and a 0.01-100 molar ratio to component A, with a B/D molar ratio being 2.2 or smaller in the reaction system. |
