Verfahren zur selektiven Ortho-Fluorierung substituierter aromatischer Verbindungen
摘要
The invention describes a process for selectively preparing ortho-fluorinated substituted aromatic compounds wherein an aromatic compound containing a substituent capable of directing ortho metalation is contacted with a metalating reagent under reaction conditions sufficient to form an ortho-metalated substituted aromatic compound. The ortho-metalated substituted aromatic compound is reacted with an electrophilic fluorinating reagent under reaction conditions sufficient to form the desired ortho-fluorinated substituted aromatic compound which is then recovered from the reaction mixture. The process which utilizes a metalation intermediate prior to effecting the electrophilic fluorination step overcomes problems associated with prior art electrophilic fluorination processes which do not proceed through a regiospecifically controlled intermediate.
申请公布号
DE69320111(D1)
申请公布日期
1998.09.10
申请号
DE1993620111
申请日期
1993.05.27
申请人
AIR PRODUCTS AND CHEMICALS, INC., ALLENTOWN, PA., US