摘要 |
The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R<SUP>1</SUP>, R<SUP>2</SUP>: optionally substituted (hetero)aryl, R<SUP>3</SUP>: -CO-R<SUP>4</SUP>, -CO-O-R<SUP>4</SUP>, etc., R<SUP>4</SUP>: alkyl, cycloalkyl, etc., A: CH<SUB>2</SUB>, CO, SO<SUB>2</SUB>, B: a single bond, etc., D: oxygen, CH<SUB>2</SUB>, E: alkylene, alkenylene, n: 1 to 3).
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