| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to compounds of general formula (I) or their pharmaceutically acceptable salts having muscarinic receptor antagonist action. In formula (I) R1 is selected from a group consisting of linear or branched (C-C)alkyl, (C-C)alkenyl, aryl(C-C)cycloalkyl, aryl(C-C)alkyl and heteroaryl optionally substituted with one or more substitutes selected from a group consisting of halogen atoms, -N(R5)(R6′), -NHCO(R5), -COR5, (C-C)alkyl, (C-C)alkoxy and aryloxy; G is selected from a group consisting of -OC(O)-, -SO- and -C(O)-; R2 is -H; R3 is selected from a group consisting of (C-C)alkyl, aryl, heteroaryl and heteroaryl (C-C)alkyl optionally substituted with one or more substitutes selected from a group consisting of halogen, -OH, (C-C)alkyl, (C-C)alkoxy, aryloxy and aryl(C-C)alkyleneoxy; R6 is selected from a group consisting of units of formula (i), (ii) and (iii), where m = 1, 2 or 3; n = 1, 2 or 3; Ais a physiologically acceptable anion; R4 represents a group of formula (Y), wherein p represents 0 or an integer from 1 to 4; q represents 0 or an integer from 1 to 4; P is absent or is selected from a group consisting of -O- and -C(O)-; W is selected from a group consisting of H, linear or branched (C-C)alkyl, aryl and heteroaryl optionally substituted with one or more substitutes selected from a group consisting of halogen, -OH, -NO, -CO(R5), (C-C)alkyl, (C-C)alkoxy and aryl; R5 and R6′ are independently selected from a group consisting from -H, (C-C)alkyl and (C-C)alkoxy. Invention also relates to compounds of general formula (VI), pharmaceutical compositions, a device comprising said composition, and use of compounds of formula (I) or (VI) for manufacture of a medicament for prevention and/or treatment of broncho-obstructive or inflammatory diseases.EFFECT: manufacture of a medicament for prevention and/or treatment of broncho-obstructive or inflammatory diseases.13 cl, 6 tbl, 52 ex |
