主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
X1 is CR6; X2 is N; X3 is CR3; X4 is N; X5 is CR6; the ring containing X1, X2, X3, X4, and X5 can be fused to ring A, ring B, or ring C; each having the formula:wherein each said ring A, ring B, or ring C is a fused 4- to 6-membered-saturated, -partially saturated, or -unsaturated-carbocyclic or -heterocyclic ring containing 0, 1, 2, or 3 heteroatoms; and is substituted by 0, 1, or 2 R10 groups; which are oxo, C1-6alk, C1-3haloalk, —OH, —OC1-4alk, —NH2—NHC1-4alk, —OC(═O)C1-4alk, or —N(C1-4alk)C1-4alk;
W is —O—; m is 0, 1, 2, 3, or 4; each of p and q is independently 0, 1, 2, 3, 4, 5, or 6; wherein the sum of p and q is 2 to 6; the ring containing p and q contains 0 or 1 double bond; R1 is halo, C1-8alk, C1-4haloalk, —ORc, —N(Ra)C(═O)Rb, —C(═O)Ra, —C(═O)Rc, —C(═O)—O—Ra, —NRaRc, —N(Rc)C(═O)Rb, —N(Ra)C(═O)Rc, —C(═O)NRaRb, —C(═O)NRaRc, or C0-4alk-L1; wherein said C1-8alk group is substituted by 0, 1, 2 or 3 groups which are halo, C1-3 haloalk,—OH, —OC1-4alk, —NH2, —NHC1-4alk, —OC(═O)C1-4alk, or —N(C1-4alk)C1-4alk;
R2 is quinolinyl, quinazolinyl, or quinoxalinyl; each of R3 and R6 is independently R1, H, halo, CN, OH, OC1-4alk, C1-4alk, or C1-4haloalk; wherein 1 or 2 of R3 and R6 must be R1; R4a is H, C1-4alk, or C1-4haloalk; each R4b is independently F, Cl, Br, CN, OH, OC1-4alk, C1-4alk, or C1-4haloalk; Ra is independently H or Rb; Rb is independently phenyl, benzyl, or C1-6alk, wherein said phenyl, benzyl, and C1-6alk are being substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4alk, C1-3haloalk, —OH, —OC1-4alk, —NH2, —NHC1-4alk, —OC(═O)C1-4alk, or —N(C1-4alk)C1-4alk; Rc is C0-4alk-L4; and each of L1, L3, and L4 is independently a carbon-linked or nitrogen-linked saturated, partially-saturated or unsaturated 3-, 4-, 5-, 6-, or 7-membered monocyclic ring or a saturated, partially-saturated or unsaturated 8-, 9-, 10-, 11-, or 12-membered bicyclic ring; each said ring contains 0, 1, 2, 3, or 4 N atoms and 0, 1, or 2 atoms which are O or S; each L1, L3, and L4 is independently substituted by 0, 1, 2 or 3 R7 groups which are independently F, Cl, Br, C1-6alk, C1-4haloalk, —ORa, —OC1-4haloalk,CN, —C(═O)Rb, —C(═O)ORa, —C(═O)NRaRa, —C(═NRa)NRaRa, —OC(═O)Rb, —OC(═O)NRaRa, —OC1-6alkNRaRa, —OC1-6alkORa, —SRa, —S(═O)Rb, —S(═O)2Rb, —S(═O)2NRaRa, —NRaRa, —NRaRc, —N(Ra)C(═O)Rb, —N(Ra)C(═O)ORb, —N(Ra)C(═O)NRaRa, —N(Ra)C(═NRa)NRaRa, —N(Ra)S(═O)2Rb, —N(Ra)S(═O)2NRaRa, —NRaC2-6alkNRaRa, —NRaC1-6 alkORa, —C1-6 alkNRaRa, —C1-6 alkORa, —C1-6 alkN(Ra)C(═O)Rb, —C1-6alkOC(═O)Rb, —C1-6alkC(═O)NRaRa, —C1-6alkC(═O)ORa, or oxo. |