Method, system, and computer program product for improving the accuracy of glucose sensors using insulin delivery observation in diabetes

摘要

Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-τ. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.

主权项

1. A processor implemented method for improving the accuracy of a glucose measurement device, said method comprising:
obtaining a glucose level readout of a subject, from said glucose measurement device; obtaining insulin delivery information from an insulin delivery device; performing a first intermediary computation using said glucose level readout from said glucose measurement device and said insulin delivery information, to obtain an output of said first intermediary computation; performing a second intermediary computation using said output of said first intermediary computation to obtain an output of said second intermediary computation; performing a third computation to reach an estimate of the blood glucose of the subject by applying a weighting scheme to said readout from the glucose measurement device and said output of said second intermediary computation; and determining, based at least in part on said estimate of the blood glucose of the subject, an amount of insulin to be delivered to the subject by the insulin delivery device; wherein the insulin delivery device is configured to deliver the determined amount of insulin to the subject.