Process for making hydroxylated cyclopentylpyrimidine compounds

摘要

The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.;

主权项

1. A compound of formula IV: or a salt thereof, wherein:
R2 is —CN, —COORa or —CONRaRb;Ra and Rb are independently hydrogen, —ORc, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted C3-8cycloalkyl, substituted or unsubstituted phenyl or substituted or unsubstituted 3 to 12 membered heterocyclyl; orRa and Rb are taken together with the atom to which they are attached to form a 3-7 membered heterocyclyl;Rc is independently hydrogen or optionally substituted C1-12 alkyl; andeach R3 is independently iodo or bromo.