| 摘要 |
(A) Cpds. of general formula (I) R and R' = H, (1-4C) alkyl, unsat. lower alkyl, opt. subst. (7-10C)aralkyl, (4-9C)N(alkyl)2, heteroalkyl with (5-8C) and (1-2 hetero) atoms, (2-4C)aliphatic acyl, (7-10C)-aroyl, or (8-12C)aralkanoyl and R2 = (1-4C)alkyl, unsat. lower alkyl, Ph, opt. subst. (7-10C) aralkyl, or (5-9C)N(alkyl)2. (B) Acid addn. salts of I. (a) Trichomonacides (b) Antiparasitics (c) Anti-cramp (d) Anti-inflammatories (e) Hypotensives. Br2 (10.3 ml.) in CHCl3 (100 ml.) was added dropwise (2 h.) to 5H-dibenzo(a,d)cycloheptene-5-carboxamide (47.0 g.) in CHCl3(1 l.), stored overnight, and filtered. The solid was refluxed 2 h. in EtOH (200 ml.) and H2O (10 ml.), evapd., washed with H2O, and recryst. from EtOH, giving the 10,5-epoxymethano-13-one m.p. 160-1 deg. |
