The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
申请公布号
US5510371(A)
申请公布日期
1996.04.23
申请号
US19940254228
申请日期
1994.06.06
申请人
MERCK & CO., INC.
发明人
SINGH, SHEO B.;GARRITY, GEORGE M.;GENILLOURD, OLGA;LINGHAM, RUSSELL B.;MARTIN, ISABEL;OMSTEAD, MARY N.;SILVERMAN, KEITH C.;ZINK, DEBORAH L.
