发明名称 |
NON-GENETICALLY MODIFIED MAMMAL AS A MODEL FOR MULTIPLE SCLEROSIS |
摘要 |
A non-human mammal genetically modified without affecting its genome and having any two of the following pathological signs: (a) a blood-brain barrier that is open or permeable to water-soluble blood molecules non-specific for the cerebral parenchyma, (b) an astrocyte disorder revealed particularly by physical network disorganisation, the disappearance of perivascular feet around the capillaries, and gliosis, (c) microglial cell activation, (d) demyelinisation plates, particularly in the brain stem and/or the cerebral white matter, and (e) central nervous system glial and endothelial cell lesions, as well as the uses of said animal, are disclosed.
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申请公布号 |
WO9733466(A1) |
申请公布日期 |
1997.09.18 |
申请号 |
WO1997FR00469 |
申请日期 |
1997.03.14 |
申请人 |
BIO MERIEUX;RIEGER, FRANCOIS;PERRON, HERVE;BENJELLOUN, NABILA |
发明人 |
RIEGER, FRANCOIS;PERRON, HERVE;BENJELLOUN, NABILA |
分类号 |
A01K67/027;C07K14/47;C07K16/18;C12N15/02;C12P21/08;C12Q1/00;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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