摘要 |
Novel compounds of formula (I) are described wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms; R2=H, CH3 or CH2CH3; R3=H or CH3; R4=H or CH3; R5= lower alkyl having from 1 to 5 carbon atoms; n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (CN), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents. |
申请人 |
UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INC.;THE CANADA TRUST COMPANY EM;DYCK, LILIAN, E.;DAVIS, BRUCE, A.;LIU, YA-DONG;DURDEN, DAVID, A.;BOULTON, ALAN, A. |
发明人 |
PATERSON, I., ALICK DI;DYCK, LILIAN, E.;DAVIS, BRUCE, A.;LIU, YA-DONG;DURDEN, DAVID, A.;BOULTON, ALAN, A. |