Intermediate Compound for Docetaxel Synthesis and Method for Its Production
摘要
<p>1. Technical Result Increase in docetaxel yield. 2. Essence A compound of the formula as an intermediate compound for docetaxel synthesis. A method comprises acylating 10-deacetyl baccatin III with at least 1,5 equivalent of n-bytil lithium and at least 1,5 equivalent of benzyl chloroformiate in tetrahydrofuran. The reaction is conducted at a low temperature - 200 C. 3. Field of Application Organic chemisry.</p>
申请公布号
GEP20002270(B)
申请公布日期
2000.07.10
申请号
GE1997AP03355
申请日期
1997.02.27
申请人
NAPRO BIOTHERAPEUTICS, INC.;BRYN MAWR COLLEGE
发明人
SISTI, NICHOLAS, J.;SWINDELL, CHARLES, S.;MADHAVI, C. CHANDER