发明名称 |
Production of multivesicular liposomes |
摘要 |
Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps. |
申请公布号 |
EP1030652(A1) |
申请公布日期 |
2000.08.30 |
申请号 |
EP19980957937 |
申请日期 |
1998.11.13 |
申请人 |
DEPOTECH CORPORATION |
发明人 |
HARTOUNIAN, HARTOUN;MEISSNER, DAGMAR;PEPPER, CLINT, B. |
分类号 |
A61J3/07;A61K9/127;A61J3/00 |
主分类号 |
A61J3/07 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|