NEW MEMBERS OF THE GLYPICAN GENE FAMILY

摘要

The invention relates to a novel polynucleotide encoding a new glypican-related protein ("glypican-6") and the gene for glypican-4 as well as derivatives of both genes for use in methods of diagnosis and therapy. Derivatives comprise for example fragments of the gene either isolated or synthetic and having a length that is smaller than the complete gene; primers, comprising at least 10 consecutive gene specific nucleotides, preferably about 20 gene specific consecutive nucleotides of the nucleotide sequence of the gene; longer oligonucleotides up to the full length of the gene; antisense variants of the gene, the fragments or the primers; antibodies directed to the gene, fragments, primers or complementary strands thereof; any specific ligand for DNA that can be used as a specific probe, peptide nucleic acid probes.