Förfarande för framställning av terapeutiskt användbart Beta-2-hydroximetyl-5-(5-fluor-cytosin-1-yl)-1,3-oxatiolan

摘要

The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, ²-BCH-189 and related compounds. Furthermore, the stereochemistry at the nucleoside 4'-position can be controlled to produce enantiomerically-enriched ²-BCH-189 and its analogues.