ANIMAL MODEL OF SCHIZOPHRENIA

摘要

A non-human transgenic animal exhibiting schizophrenic symptoms in which a polynucleotide encoding SREB2 whose overexpression in brain causes schizophrenia and a polynucleotide containing a promoter have been introduced; and a screening method for a therapeutic agent for schizophrenia comprising the steps of administering a test substance to the animal, determining disorders associated with schizophrenia of the animal administered with the test substance, and selecting a substance having a therapeutic effect on schizophrenia are disclosed. According to the invention, an animal model of schizophrenia which reflects the genetic background causing the onset of schizophrenia and an in vivo screening method for a therapeutic agent for schizophrenia can be provided.