Chimeric respiratory syncytial virus (RSV) polypeptide antigens are provided. The disclosed polypeptides include in an N-terminal to C-terminal direction: a first F protein polypeptide domain; a G protein polyeptpide domain; and a second F protein polypeptide domain. The disclosure also provides nucleic acids that encode, and pharmaceutical compositions that contain, the chimeric RSV polypeptides, as well as methods for their production and use.
申请公布号
WO2008114149(A2)
申请公布日期
2008.09.25
申请号
WO2008IB01286
申请日期
2008.03.20
申请人
ID BIOMEDICAL CORPORATION OF QUEBEC;BLAIS, NORMAND;BURT, DAVID, S.;CYR, SONYA, L.;MARTIN, DENIS, L.;RHEAULT, PATRICK
发明人
BLAIS, NORMAND;BURT, DAVID, S.;CYR, SONYA, L.;MARTIN, DENIS, L.;RHEAULT, PATRICK