发明名称 |
Glycosyltransferase gene and use thereof |
摘要 |
Provided is a polynucleotide encoding a protein having an activity to transfer a sugar to the hydroxy groups at the 4′- and 7-positions of a flavone. The polynucleotide is selected from the group consisting of: (a) a polynucleotide which comprises a base sequence represented by SEQ ID NO: 1, 3, or 12; (b) a polynucleotide which hybridizes to a polynucleotide comprising a base sequence complementary to a base sequence represented by SEQ ID NO: 1, 3, or 12 under high stringency conditions, and encodes a protein having an activity to transfer a sugar to the hydroxy groups at the 4′- and 7-positions of a flavone; (c) a polynucleotide which encodes a protein comprising an amino acid sequence represented by SEQ ID NO: 2, 4, or 13; (d) a polynucleotide which encodes a protein comprising an amino acid sequence in which one or more amino acids have been deleted, substituted, inserted, and/or added in an amino acid sequence represented by SEQ ID NO: 2, 4, or 13 and having an activity to transfer a sugar to the hydroxy groups at the 4′- and 7-positions of a flavone; etc. |
申请公布号 |
US9365836(B2) |
申请公布日期 |
2016.06.14 |
申请号 |
US201213979717 |
申请日期 |
2012.01.11 |
申请人 |
SUNTORY HOLDINGS LIMITED |
发明人 |
Tanaka Yoshikazu;Okitsu Naoko;Matsui Keisuke |
分类号 |
C12N9/10;C12N15/82;C07H17/07;C12P19/18;A23L1/305;A61K8/60;A61Q19/00;C12P19/46;C12P19/60 |
主分类号 |
C12N9/10 |
代理机构 |
Drinker Biddle & Reath LLP |
代理人 |
Drinker Biddle & Reath LLP |
主权项 |
1. A polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising SEQ ID NO: 1; and (b) a polynucleotide which encodes a protein comprising an amino acid sequence in which one to five amino acids have been deleted, substituted, inserted, and/or added in the amino acid sequence defined in SEQ ID NO: 2 and having an activity of transferring a glycosyl to both of the hydroxyl groups at 4′- and 7-positions of a flavone. |
地址 |
Osaka-shi, Osaka JP |