| 发明名称 |
THERAPEUTIC ASPARAGINASES |
| 摘要 |
Provided herein are mutant asparaginase enzymes that lack glutaminase activity. Also provided are methods of treating ASNS-negative cancer cells with a glutaminase-free asparaginase. |
| 申请公布号 |
US2016213759(A1) |
申请公布日期 |
2016.07.28 |
| 申请号 |
US201414917934 |
申请日期 |
2014.09.10 |
| 申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ;SANDIA CORPORATION ;UNIVERSITY OF MARYLAND |
发明人 |
REMPE Susan;ROGERS David M.;ANISHKIN Andriy;SUKHAREV Sergei;LORENZI Philip L.;CHAN Wai Kin;WEINSTEIN John N. |
| 分类号 |
A61K38/50;C12N9/96;C12N9/82;A61K47/48;A61K45/06 |
主分类号 |
A61K38/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated, modified L-asparaginase (L-ASP) enzyme having at least one substitution relative to a native L-ASP amino acid sequence (see SEQ ID NO: 9), said at least one substitution including a glycine, threonine, or alanine at position 58 or a leucine or phenylalanine at position 59 of the native L-ASP sequence. |
| 地址 |
Austin TX US |
