摘要 |
1,058,356. Bis - (pyridyl-methyl) - amine. STAROGARDZKIE ZAKLADY FARMACEUTYCZNE " POLFA " PRZEDSIEBIORSTWO PAVSTWOWE. Nov. 29, 1965 [Nov. 27, 1964], No. 50618/65. Heading C2C. Bis-(pyridylmethyl)-amines are prepared by converting a pyridine aldehyde into the corresponding oxime, subjecting the oxime to hydrogenation, coupling the amine obtained without separation with a pyridine aldehyde, and hydrogenating the Schiffs base product of the coupling to give the bis-(pyridylmethyl)amine. The pyridine aldehyde starting material may be in the form of a salt and the hydrogenations are preferably effected catalytically using Raney nickel. |