| 摘要 |
1410715 Modified hydrophilic polymers CESKOSLOVENSKA AKADEMIE VED 21 Feb 1973 [29 Feb 1972] 8539/73 Heading C3P Water-soluble polymers, solutions of which can be used as a substitute for blood plasma, are obtained by (a) preparing a water-soluble primary polymer or copolymer having a weight average M.W. of 10,000-60,000 and containing not more than 1 wt. per cent of material having a M.W. above 100,000, the polymer or copolymer being derived from one or more monomers selected from N-alkyl methacrylamides, N-alkyl acrylamides, N,N,-dialkyl acrylamides, N - acryloylmorpholine and monoesters of acrylic or methacrylic acid with di- or higher-polyethylene glycols (the alkyl groups in these monomers may be substituted by hydroxy, amino or alkoxy groups), the polymer or copolymer containing reactive hydrogen atoms (the use of N,N,dialkyl acrylamides alone is disclaimed, unless the alkyl groups are substituted by groups containing reactive hydrogen, and the use of N-acryloylmorpholine alone is also disclaimed); and (b) reacting the primary polymer or copolymer with a compound which is at least bifunctional and contains groups which react with the said active hydrogen atoms to increase the average M.W. of the polymer or copolymer to 60,000-250,000 whilst retaining water-solubility. Up to 49 mol per cent of the polymer or copolymer may be derived from other monomers containing an -NH-group. In examples, a homopolymer of N-(2-hydroxypropyl)methacrylamide and the copolymers N - ethyl methacrylamide / acrylamide, N - ethyl methacrylamide / p - amino styrene, diethylene glycol monomethacrylate / tetraethylene glycol monomethacrylate / ethylaminoethyl methacrylate, triethylene glycol monomethacrylate / N,N - diethyl acrylamide/ N - (2 - aminobutyl) - acrylamide and triethylene glycol monoacrylate / N - acryloyl morpholine / methylaminoethyl acrylate are prepared, and are then reacted with reactants selected from hexamethylene diisocyanate, toluene - 2,4 (or 2,6) - diisocyanate, phosgene, glutaric acid dichloride, glutaric dialdehyde and hexamethoxymethyl melamine. |
