发明名称 |
Process for 6-O-alkylation of erythromycin derivatives |
摘要 |
A procedure for preparing 6-O-alkyl erythromycin compounds having the formula: <IMAGE> wherein R1 is a loweralkyl group, R2 and R3 are independently hydrogen or a hydroxy-protecting group, except that R2 and R3 may not both be hydrogen simultaneously; Y is oxygen or a specifically substituted oxime; and Z is hydrogen, hydroxy or protected-hydroxy; by reaction of the compound wherein R1 is hydrogen with an alkylating reagent, in the presence of a strong alkali metal base and also in the presence of a weak organic amine base, in a suitable stirred or agitated polar aprotic solvent, or a mixture of such polar aprotic solvents maintained at a reaction temperature and for a period of time sufficient to effect alkyation.
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申请公布号 |
US5872229(A) |
申请公布日期 |
1999.02.16 |
申请号 |
US19950560752 |
申请日期 |
1995.11.21 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
LIU, JIH-HUA;FOSTER, JR., GEORGE A.;MONTGOMERY, STEPHEN H. |
分类号 |
C07H17/08;(IPC1-7):C07H1/00 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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