| 发明名称 |
Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity |
| 摘要 |
Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.
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| 申请公布号 |
USRE36397(E) |
申请公布日期 |
1999.11.16 |
| 申请号 |
US19980219843 |
申请日期 |
1998.12.23 |
| 申请人 |
THE JOHN HOPKINS UNIVERSITY;THE UNITED STATES OF AMERICA |
发明人 |
ZHANG, JIE;DAWSON, VALINA L.;DAWSON, TED M.;SNYDER, SOLOMON H. |
| 分类号 |
A61K31/165;A61K31/47;(IPC1-7):A61K31/165 |
主分类号 |
A61K31/165 |
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