MAMMALIAN TOLLOID-LIKE GENE AND PROTEIN

摘要

PURPOSE: A target molecule is provided to be related to the accumulation of extracellular matrix in a back-bone animal and to develop a medicine having a lowering activation for a tolloid-like protein for treating scarring, fibrosis, and the like. CONSTITUTION: A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.