THERAPEUTIC APPLICATIONS OF FLINT POLYPEPTIDES

摘要

Mature FLINT protein (mFLINT) binds FasL and LIGHT, and prevents FasL-Fas interaction. mFLINT inhibits FasL-Fas-mediated apoptotic and proinflammatory activity, and is useful in treating disorders that may be associated with abnormal apoptosis and inflammation. The invention provides the amino acid and nucleotide sequences of FLINT and mature FLINT. Therapeutic compositions and methods of treatment utilizing mFLINT also are provided.