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发明名称
辅酶NAD及其组合物在细胞保护药物中的应用
摘要
本发明公开辅酶NAD及其组合物在细胞保护药物中的应用。NAD能够促进人体内红细胞的生成,与化疗同时应用可改善贫血状态。该酶能预防正常组织细胞免受化学和辐射损伤以及凋亡产生。NAD处理的H22细胞具有较强免疫原性,能激发机体产生特异性抗肿瘤免疫,是一种良好的肿瘤疫苗,其抗肿瘤效应是由表达在肿瘤细胞膜上的HSP70蛋白所介导。NAD有增强胃粘液屏障,促进溃疡愈合作用。NAD有抗氧化和抗衰老,保护细胞膜并预防细胞的坏死和突变以及防治肝纤维化作用。
申请公布号
CN1264599A
申请公布日期
2000.08.30
申请号
CN00114011.6
申请日期
2000.01.10
申请人
第一军医大学珠江医院
发明人
张积仁;徐萌
分类号
A61K38/43;A61P39/00
主分类号
A61K38/43
代理机构
代理人
主权项
1.辅酶NAD及其组合物在细胞保护药物中的应用特征在于:(1)能保护造血干细胞,即能刺激造血又能保护造血干细胞免受放射和化疗毒性损伤,是骨髓的保护因子。(2)能保护正常组织细胞免受化学和辐射损伤,利用正常组织和肿瘤组织之间NAD浓度的差别,可以达到正常组织细胞免受放化疗损伤而又不影响放化疗最佳疗效的目的,用于肿瘤患者放化疗毒性防治药物。(3)NAD是一种良好的免疫增强剂,能激发机体产生特异性抗肿瘤免疫。(4)NAD有增强胃粘液和黏膜屏障,降低幽门螺杆菌感染发生率,促进溃疡愈合作用。(5)NAD有抗氧化和抗衰老作用,保护细胞膜并预防细胞的坏死和突变以及能防治肝纤维化。
地址
510282广东省广州工业大道523号
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