Methods and compositions for modifying sensorial perception

摘要

Compounds and methods for modifying sensory perception associated with transient sensory receptors TRPA1, TRPV1, and TRPA1V1. A method for screening compounds for modulation of TRPA1, TRPV1, and/or TRPA1V1. Compositions comprising TRPA1V1 agonists or antagonists, for modifying sensory perception of the compositions.

主权项

1. A method of altering the sensory perception of burning, irritation, or pain from exposure to an oral care composition, the method comprising:
incorporating a compound that modulates TRPA1V1 activity into an oral care composition; wherein the compound is trans,trans-2,4-undecadien-1-al; wherein the compound is present in an amount effective to reduce the activation of TRPA1V1 relative to the activation of at least one of TRPA1 or TRPV1.