Anti-human OX40L antibodies and methods of treating graft versus host disease with the same

摘要

The present invention relates to anti-human OX40L antibodies, new medical uses and methods.

主权项

1. A method of treating or preventing graft versus host disease (GvHD) in a human subject in need thereof, comprising:
administering an anti-OX40L antibody or fragment thereof that antagonizes specific binding of OX40 to OX40L to a subject determined to have a ratio of CD45RA+CCR7+CD95+OX40+ T stem cell memory (Tscm) cells to CD45RA+CCR7+CD95− T-naive (Tn) cells greater than 50:50 wherein the antibody or fragment thereof is administered in an amount effective to reduce the ratio of said Tscm cells in said human, wherein a blood sample obtained from the human subject has been subjected to an assay to measure the ratio of CD45RA+CCR7+CD95+OX40+ Tscm:CD45RA+CCR7+CD95− Tn cells in the sample.