| 发明名称 | Sorbent for endotoxins | ||
| 摘要 | The invention relates to a sorption agent for removing endotoxins from a biological fluid, comprising a water-insoluble, porous carrier having a neutral hydrophobic surface wherein the surface of the carrier has an adsorptive coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the carrier in a noncovalent manner. The invention further relates to a method for producing such a sorption agent. The sorption agent is used in extracorporeal blood purification, in particular in order to treat individuals, who have sepsis. | ||
| 申请公布号 | US9440019(B2) | 申请公布日期 | 2016.09.13 |
| 申请号 | US201113806184 | 申请日期 | 2011.06.22 |
| 申请人 | Fresenius Medical Care Deutschland GmbH | 发明人 | Falkenhagen Dieter;Harm Stephan;Hartmann Jens;Weber Viktoria |
| 分类号 | A61M1/36;B01J20/32;A61M1/34;B01J20/26;B01J20/28 | 主分类号 | A61M1/36 |
| 代理机构 | Sutherland Asbill & Brennan LLP | 代理人 | Sutherland Asbill & Brennan LLP |
| 主权项 | 1. A sorption agent for removing endotoxins from blood or blood plasma, comprising: a water-insoluble, porous carrier having a neutral hydrophobic surface wherein the surface of the carrier has an adsorptive coating made of polymyxin B and human serum albumin, wherein the polymyxin B and human serum albumin are noncovalently attached to the surface of the carrier by a hydrophobic interaction. | ||
| 地址 | Bad Homburg DE | ||