Agent that inhibits angiogenesis and metastasis targeting mTOR signaling pathway

摘要

The present invention relates to a novel function of Msx1 protein for inhibiting tumor angiogenesis and metastasis by targeting mTOR (mammalian target of rapamycin) signaling pathway, and for treating a cancer in a subject. Particularly, Msx1 suppresses mTOR through a direct interaction with mTOR, resulting in the inhibition of angiogenesis. The Msx1 significantly suppresses tumor angiogenesis that is necessary for the growth, invasion, and metastasis of solid tumors. Ad-Msx1 can be used to effectively inhibit tumor metastasis by suppressing angiogenesis, tumor cell invasion, and migration.

主权项

1. A method of inhibiting angiogenesis of vascular endothelial cell in a subject with a tumor, the method comprising
selecting a subject with tumor vascular endothelial cells having upregulation of the mTOR pathway; and administering to said subject a therapeutically effective amount of Msx1 protein comprising the amino acid sequence of SEQ ID NO:1, wherein inhibition of angiogenesis is achieved by direct interaction of the Msx1 protein with mTOR resulting in downregulation of mTOR.