Compounds and compositions for the treatment of cancer

摘要

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.

主权项

1. A method for inhibiting tumor cell migration and establishment of metastasis in a subject suffering from cancer, wherein said method comprises administering to the subject a compound represented by Formula IA, or a pharmaceutically acceptable salt thereof:wherein
R2 and R3 are independently selected from H, OH, F or Cl; X1 is (CH2)n, wherein n is 0, 1 or 2; and R4 is (CH2)m1, (CH2)q1CH═CH, or CH═CH(CH2) wherein m1 is 4, 5 or 6 and q1 is 2, or 3.