Process for the preparation of fused pyridine compounds.

摘要

2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl)pyrido[2,3-d]pyr imidin e s and 2-amino-4-hydroxy-6[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyri midines are prepared through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents. A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.