| 摘要 |
NEW MATERIAL:A compound shown by formula I [Y is -O- or group shown by formula II (R<3> is H or alkyl); A is group shown by formula III (n is 1-5; R<4> is R<3>, cycloalkyl, etc.), group shown by formula IV or formula V; R<1> is R<3>, halogen, CF3, OH, alkoxy, amino, etc.; R<2> is R<3>, halogen, OH, alkoxy, aralkyloxy, amino, nitro, etc.]. EXAMPLE:2-Methyl-imidazo[1,2-a]pyridine-3-carboxylic acid (endo-8-methyl-8- azabicyclo[3,2,1]oct-3-yl)ester hydrochloride. USE:A drug. 5-HT antagonist. Useful for treating or preventing migraine, etc., antiemetic, especially preventing vomiting and bad heart related to treatment of cancer, remedying central nerve disorder, arrhythmia, etc. and useful for treating delayed gastric emptying, digestive ulcer, etc. PREPARATION:A compound shown by formula VI or a reactive derivative is condensed with a compound shown by formula VII or a precursor thereof in a solvent to give a compound shown by formula I. |
