| 摘要 |
<p>The present invention is related to a method for selecting pathogen inhibiting substances with high affinity and neutralizing effect by competitive elution using neutralizing substances. The method and system is useful for comparative drug design to provide therapeutically active, protective and/or prophylactic substances and developing combinatorial therapies as well as for pathogen diagnostics. The invention also discloses methods for identifying the mimotype characteristics of the neutralization site of pathogens, especially enveloped viruses, such as hantavirus, respiratory syncytial virus (RSV), etc. The invention is further related to ligands obtainable by the method as well as consensus sequences and parts and repeats of said ligands for use in test kits containing combinatorial ligand libraries comprising the ligands selected by the method.</p> |
