METHOD FOR THE PREPARATION OF AZITROMYCINDIHYDROCHLORIDE

摘要

By the method azitromycindihydrochloride is produced which isa pharmacologically acceptable salt of the antibiotic azitromycinused as an antibacterial agent with a wide spectrum of effect.Azitromycinmonohydrate or dihydrate dissolved in lower alcohol orlower keton reacts with 1.6-2 equivalents of gaseous hydrogenchloride dissolved in dry lower alcohol. The product produced issettled by means of ether as an agent which does not dissolve itand is then filtered.2 claims