CONTROLED RELEASE OF OXYCODONE COMPOSITIONS

摘要

The method for considerable reduction of the amount of thedaily dose required for controlling the pain in approximately 90%of the patients includes the application of oral dose ofcontrolled released oxycodone from 10 to 40 mg oxycodone or itssalt. The form secures maximum plasma content of the oxycodonefrom 6 to 60 ng/ml of the medicament from 2 to 4 1/2 hrs afterapplication and minimum plasma concentration from 3 to 30 ng/mlfrom 10 to 14 hrs after repeated application every 12 hours atconstant conditions. Another alternative implementation forcontrolling the pain in all patients is the application of oralsolid form including up to 160 mg oxycodone or its salt, so thatits maxymum plasma concentration would reach up to 240 ng/ml fromthe medicament from 2 to 4 1/2 hrs after aplication the minimumplasma concentration approaching 120 ng/ml from 10 to 14 hrs afterrepeated application every 12 hours under constant conditions. Theinvention also includes oxycodone forms for attaning the aboveconcentrations.