| 摘要 |
<p>The invention provides a peptide suitable for the prophylaxis, treatment diagnosis or monitoring of arthritis, said peptide comprising a contiguous sequence of 9 amino acid residues (nonapeptide), said nonapeptide complying with the amino acid sequence: X1-X2-X3-X4-X5-X6-X7-X8-X9, wherein X2, X6 and X7 are any amino acid, X1 is any amino acid except K,H,R,E,D; X3 is S or T; X4 is one of F,L,I,V,A,G,C,P; X5 is one of A,G,C,P,S,N,T,V; X8 is one of V,L,I,M; X9 is E or D; and being a part of a mammalian cartilage, joint or arthritis-related protein such as collagen or a cartilage protein, said peptide having a length of 9-20 amino acids and being capable of being recognised by freshly isolated T cells from rats in which Adjuvant Arthritis is induced and/or being capable of being recognised in vitro by T cell clone A2b.</p> |
