摘要 |
N-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl-acetamide derivatives (I) are used for treating and preventing irritable bowel syndrome. N-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl-acetamide derivatives of formula (I) are used for treating and preventing irritable bowel syndrome. R<1> = Ar, 3-7C cycloalkyl, or 4-8C cycloalkylalkyl; R<2> = Ar; or R<1>+R<2> = form a group of formula (i); R<3> = H, OH, OA or A; R<4> = A or phenyl (both optionally substituted by one or two halo, OH, OA, CF3, NO2, NH2, NHA, NHCOA, NHSO2 or NA2); R<5> = OH or CH2OH; R<6>, R<7> = H, halo, OH, OA, CF3, NH2, NHA, NA2, NHCOA, NHCONH2, NO2 or methylenedioxy; A = 1-7C alkyl; Ar = mono- or bicyclic aromatic group (optionally containing one N, O or S and/or substituted by 1-3 A, halo, OH, OA, CF3, NH2, NHA, NA2, NHCOA and/or NHCONH2; and D' = CH2, O, S, NH, NA, CH2CH2, CH=CH, CH2NH, CH2NA or a bond.
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