5-GLYCOSYLOXY-6-HYDROXYNAPHTHO[2,3-f]QUINOLINE-7,12-DIONE HAVING ANTICANCER ACTIVITIES

摘要

Novel compounds represented by the general formula (I) or salts thereof, which are reduced in toxicity and improved in anticancer activity as compared with known carcinostatic anthracycline derivatives (I), (wherein A is methyl or CF3; B is hydrogen or an electron-withdrawing group such as halogeno, provided that when A is CF3, B is hydrogen, while when A is methyl, B is an electron-withdrawing group; and R<1> and R<2> are each hydroxyl or the like). Novel water-soluble carcinostatic compounds, represented by general formula (V), (wherein A and B are each as defined above; and R<5>, R<6> and R<7> are each hydrogen or an omega -amino acid residue, with the proviso that the cases wherein all of R<5>, R<6> and R<7> are hydrogen are excepted).