PURIFICATION METHOD OF PRAVASTATIN PRECURSOR COMPACTIN AND DERIVATIVES THEREOF USING HP20 RESIN AND ETHANOL

摘要

PURPOSE: A purification method of pravastatin precursor compactin and derivatives thereof is provided particularly by absorption chromatography using ethanol and HP20 resin. CONSTITUTION: The purification method of pravastatin precursor compactin and its derivatives comprises the steps of: fermenting strains which produce compactin and its derivatives in order to obtain a fermentation solution; performing absorption chromatography with the fermentation solution using ethanol and HP20 resin; and recovering pravastatin precursor compactin and its derivatives by using ethanol, wherein the absorption chromatography is performed at 0-20% of the ethanol content in absorption solution with maintaining the ethanol content in eluting solution to 60% or more.