THIOPEPTIDE COMPOUND

摘要

It is intended to provide a novel thiopeptide compound represented by the formula (I) obtained by subjecting a known thiopeptide compound QN3323-A substance to oximation and acylation at the 2- and 26-positions and a salt thereof. The compound has a good antimicrobial activity, particularly has an excellent antimicrobial activity against multidrug resistant bacteria such as MRSA and VRE, and is useful as a pharmaceutical, particularly an antimicrobial agent, more particularly a preventive and/or therapeutic agent for multidrug resistant bacterial infection. (I) In the formula, the symbols have the following meaning. R<SUP>1</SUP> represents lower alkyl which may have a substituent or the like; R<SUP>2</SUP> represents -ALK-COORa, -ALK- (heteroaryl which may have a substituent), -ALK- (aryl which may have a substituent), or -ALK-NRbRc; ALK represents a lower alkylene group; Ra represents H or lower alkyl; Rb and Rc are the same or different, and represent H or lower alkyl or are combined with the adjacent nitrogen atom to form a 5- to 8-membered nitrogen-containing saturated cyclic group which may have a substituent.