发明名称 |
PIG MODEL FOR BREAST CANCER, MITOCHONDRIA RELATED PROTEIN FOLDING DISORDERS AND/OR EPIDERMOLYSIS BULLOSA SIMPLEX |
摘要 |
The present invention relates to a genetically modified pig as a model for studying breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex. The modified pig model displays one or more phenotypes associated with any of said disorders. Disclosed is also a modified pig comprising a modified endogeneous BRCA1 and/or BRCA2 gene, and/or a modified ornithine transcarbamylase gene, and/or a modified Keratin 14 gene and/or a transcriptional or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from breast cancer, mitochondria related protein folding disorders and/or epidermolysis bullosa simplex are disclosed.
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申请公布号 |
CA2717251(A1) |
申请公布日期 |
2008.09.12 |
申请号 |
CA20082717251 |
申请日期 |
2008.03.06 |
申请人 |
AARHUS UNIVERSITET |
发明人 |
KRAGH, PETER MICHAEL;BOLUND, LARS AXEL;SOERENSEN, CHARLOTTE BRANDT;CORYDON, THOMAS JUHL;GREGERSEN, NIELS;BROSS, PETER |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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