| 发明名称 | Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof | ||
| 摘要 | The present invention relates to novel virus-like particles (VLPs) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus. The target polypeptide may be antigenic or therapeutic. The first and the second plant enveloped viruses may be the same. Either plant enveloped virus may be a plant rhabdovirus. Also provided are methods of making and using the VLPs. | ||
| 申请公布号 | US9364530(B2) | 申请公布日期 | 2016.06.14 |
| 申请号 | US201314379408 | 申请日期 | 2013.03.15 |
| 申请人 | Fraunhofer USA, Inc. | 发明人 | Prokhnevsky Alexei;Yusibov Vidadi |
| 分类号 | A61K39/205;A61K39/145;C07K14/005;C12N7/00;C12N15/82;C12P21/02;A61K39/12;A61K39/00 | 主分类号 | A61K39/205 |
| 代理机构 | RatnerPrestia | 代理人 | RatnerPrestia |
| 主权项 | 1. A virus-like particle comprising a matrix protein from a first plant enveloped virus and a surface polypeptide, wherein the first plant enveloped virus is a plant rhabdovirus, and wherein the surface polypeptide comprises (a) a surface exposed portion from a target polypeptide wherein the target polypeptide is a polypeptide not from the first plant enveloped virus, (b) a transmembrane domain, and (c) a cytosolic tail from a transmembrane protein of a second plant enveloped virus. | ||
| 地址 | Newark DE US | ||