发明名称 |
Relaxin fusion polypeptides and uses thereof |
摘要 |
The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides. |
申请公布号 |
US9382305(B2) |
申请公布日期 |
2016.07.05 |
申请号 |
US201214130493 |
申请日期 |
2012.06.29 |
申请人 |
BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
Wilmen Andreas;Haupts Ulrich;Freiberg Christoph;Trautwein Mark;Linden Lars;Leineweber Kirsten;Tinel Hanna |
分类号 |
C07K14/64;C07K19/00;A61K38/22;C12N15/16;C07K16/18;A61K38/00 |
主分类号 |
C07K14/64 |
代理机构 |
|
代理人 |
Blankinship Thomas C.;Ji Yonggang |
主权项 |
1. A fusion polypeptide having Relaxin activity comprising A-L-B,wherein
B comprises a Relaxin 2 B chain polypeptide, A comprises a Relaxin 2 A chain polypeptide, and L is a linker polypeptide, wherein the linker polypeptide L is 6-14 amino acids in length. |
地址 |
Monheim DE |