Process for preparation of dronedarone by oxidation of a hydroxyl group

摘要

The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof (formula I), which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.;

主权项

1. A process for the preparation of dronedarone (I)or a pharmaceutically acceptable salt thereof comprising the steps of:
(a) oxidizing a compound of formula (VI) or a salt thereof, (b) isolating the obtained product, and (c) optionally converting the product into a pharmaceutically acceptable salt thereof.