Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution

摘要

Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

主权项

1. A method for controlling a red blood cell exchange procedure for a patient by means of a blood processing system with a programmable controller having an operator interface so as to achieve isovolemic hemodilution prior to infusion of replacement red blood cells to the patient, the method comprising:
entering into the operator interface of the controller a target dilution hematocrit and a target end hematocrit for the patient; entering into the operator interface an identification of a cell-free replacement fluid; calculating with the programmable controller an amount of whole blood to be processed to achieve the target dilution hematocrit; processing whole blood from the patient to remove patient red blood cells and returning said replacement fluid to the patient with the blood processing system; monitoring with the programmable controller the amount of whole blood processed to achieve the target dilution hematocrit; and continuing the processing of whole blood and returning infusing the replacement red blood cells to the patient to achieve the target end hematocrit.